The town is a center of the light and processing industry: wood industring, production of shoes, knitted fabrics, ready-made clothes, children toys, packaging, bread production, printing industry, and tinned food industry. There are enterprises for production of condensers, silo transformers, household and kitchen furnishing, and joinery work. In recent years hotel keeping and tourism have been developing as well. The region has traditions in the field of fruit-growing and trade with fresh and dried fruits. Kyustendil is a center of an agricultural region of century-old traditions in the field of fruit-growing, and hence the town and its proximity are known as the "fruit garden of Bulgaria".
The 2018 Gross Domestic Product (GDP) per capita in the region was BGN 9 285.